Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma.

ABSTRACT: Obese asthmatics tend to have severe, poorly controlled disease and exhibit methacholine hyperresponsiveness manifesting in proximal airway narrowing and distal lung tissue collapsibility. Substantial weight loss in obese asthmatics or in mouse models of the condition decreases methacholine hyperresponsiveness. Ketone bodies are rapidly elevated during weight loss, coinciding with or preceding relief from asthma-related comorbidities. As ketone bodies may exert numerous potentially therapeutic effects, augmenting their systemic concentrations is being targeted for the treatment of several conditions. Circulating ketone body levels can be increased by feeding a ketogenic diet or by providing a ketone ester dietary supplement, which we hypothesized would exert protective effects in mouse mod

SUBMITTER: Mank MM 

PROVIDER: S-EPMC8782644 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature