Determinants and protective associations of the lupus low disease activity state in a prospective Chinese cohort.

ABSTRACT:

Objective

To investigate the frequency and determinants of achieving the lupus low disease activity state (LLDAS), and the effect of LLDAS attainment on disease flare and damage accrual in a prospective, single-center cohort of Chinese lupus patients.

Methods

Baseline and follow-up data from consecutive patients at the Peking University First Hospital were collected from January 2017 to June 2020.

Results

A total of 185 patients were enrolled, with median (range) disease duration at enrolment of 2.3 (0.8-7.7) years, and median follow-up of 2.2 (1.0-2.9) years. By the end of the study, 139 (75.1%) patients had achieved LLDAS at least once; 82 (44.3%) patients achieved LLDAS for ≥ 50% of observations. Multivariable logistic regression analysis showed that 24-h urinary t

SUBMITTER: Hao Y 

PROVIDER: S-EPMC8782788 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature