Efficacy and safety of intravenous immunoglobulins for the treatment of viral encephalitis: a systematic literature review.

ABSTRACT:

Background

For most viral encephalitides, therapy is merely supportive. Intravenous immunoglobulins (IVIG) have been used as a prophylactic and therapeutic approach. We conduct a systematic review on the safety and efficacy of IVIG in viral encephalitis.

Methods

We conducted a systematic review assessing PubMed, Cochrane Database, Biosis Previews and the ClinicalTrials.gov website to identify all reports on patients with viral encephalitis treated with IVIG as of May 31, 2019. The main outcomes assessed were therapeutic efficacy and safety. For an increased homogeneity of the population, atypical viral infections were excluded, as were reports on prophylactic IVIG use, intrathecal application of immunoglobulins, or use of antibody-enriched IVIG-preparations. Data were extrac

SUBMITTER: Wagner JN 

PROVIDER: S-EPMC8782811 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature