N6-methyladenosine demethylase FTO promotes growth and metastasis of gastric cancer via m⁶A modification of caveolin-1 and metabolic regulation of mitochondrial dynamics.

ABSTRACT: Gastric cancer (GC) is the fifth most common tumor and the third most deadly cancer worldwide. N6-methyladenosine (m⁶A) modification has been reported to play a regulatory role in human cancers. However, the exact role of m⁶A in GC remains largely unknown, and the dysregulation of m⁶A on mitochondrial metabolism has never been studied. In the present study, we demonstrated that FTO, a key demethylase for RNA m⁶A modification, was up-regulated in GC tissues, especially in tissues with liver metastasis. Functionally, FTO acted as a promoter for the proliferation and metastasis in GC. Moreover, FTO enhanced the degradation of caveolin-1 mRNA via its demethylation, which regulated the mitochondrial fission/fusion and metabolism. Collectively, our cur

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC8782929 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature