Identifying Patients at Risk for Fibrosis in a Primary Care NAFLD Cohort.

ABSTRACT:

Goals and background

Using natural language processing to create a nonalcoholic fatty liver disease (NAFLD) cohort in primary care, we assessed advanced fibrosis risk with the Fibrosis-4 Index (FIB-4) and NAFLD Fibrosis Score (NFS) and evaluated risk score agreement.

Materials and methods

In this retrospective study of adults with radiographic evidence of hepatic steatosis, we calculated patient-level FIB-4 and NFS scores and categorized them by fibrosis risk. Risk category and risk score agreement was analyzed using weighted κ, Pearson correlation, and Bland-Altman analysis. A multinomial logistic regression model evaluated associations between clinical variables and discrepant FIB-4 and NFS results.

Results

Of the 767 patient cohorts, 71% had a FIB-4 or NFS score in

SUBMITTER: Schreiner AD 

PROVIDER: S-EPMC8782936 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature