A three-factor model of common early onset psychiatric disorders: temperament, adversity, and dopamine.

ABSTRACT: Commonly comorbid early onset psychiatric disorders might reflect the varying expression of overlapping risk factors. The mediating processes remain poorly understood, but three factors show some promise: adolescent externalizing traits, early life adversity, and midbrain dopamine autoreceptors. To investigate whether these features acquire greater predictive power when combined, a longitudinal study was conducted in youth who have been followed since birth. Cohort members were invited to participate based on externalizing scores between 11 to 16 years of age. At age 18 (age 18.5 ± 0.6 y.o.), 52 entry criteria meeting volunteers had a 90-min positron emission tomography scan with [¹⁸F]fallypride, completed the Childhood Trauma Questionnaire, and were assessed with the Structured

SUBMITTER: Iqbal M 

PROVIDER: S-EPMC8783001 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature