Tracking the circulating SARS-CoV-2 variant of concern in South Africa using wastewater-based epidemiology.

ABSTRACT: This study uses wastewater-based epidemiology (WBE) to rapidly and, through targeted surveillance, track the geographical distribution of SARS-CoV-2 variants of concern (Alpha, Beta and Delta) within 24 wastewater treatment plants (WWTPs) in the Western Cape of South Africa. Information obtained was used to identify the circulating variant of concern (VOC) within a population and retrospectively trace when the predominant variant was introduced. Genotyping analysis of SARS-CoV-2 showed that 50% of wastewater samples harbored signature mutations linked to the Beta variant before the third wave, with the Delta variant absent within the population. Over time, the prevalence of the beta variant decreased steadily. The onset of the third wave resulted in the Delta variant becoming the predomina

SUBMITTER: Johnson R 

PROVIDER: S-EPMC8783013 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature