An Integrative Genomic Strategy Identifies sRAGE as a Causal and Protective Biomarker of Lung Function.

ABSTRACT:

Background

There are few clinically useful circulating biomarkers of lung function and lung disease. We hypothesized that genome-wide association studies (GWAS) of circulating proteins in conjunction with GWAS of pulmonary traits represents a clinically relevant approach to identifying causal proteins and therapeutically useful insights into mechanisms related to lung function and disease.

Study question

Can an integrative genomic strategy using GWAS of plasma soluble receptor for advanced glycation end-products (sRAGE) levels in conjunction with GWAS of lung function traits identify putatively causal relations of sRAGE to lung function?

Study design and methods

Plasma sRAGE levels were measured in 6,861 Framingham Heart Study participants and GWAS of sRAGE was conduc

SUBMITTER: Keefe J 

PROVIDER: S-EPMC8783029 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature