Ontology highlight
ABSTRACT:
SUBMITTER: Aykroyd BRL
PROVIDER: S-EPMC8783045 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Aykroyd Bethany R L BRL Tunster Simon J SJ Sferruzzi-Perri Amanda N AN
Development (Cambridge, England) 20220104 1
Imprinting control region (ICR1) controls the expression of the Igf2 and H19 genes in a parent-of-origin specific manner. Appropriate expression of the Igf2-H19 locus is fundamental for normal fetal development, yet the importance of ICR1 in the placental production of hormones that promote maternal nutrient allocation to the fetus is unknown. To address this, we used a novel mouse model to selectively delete ICR1 in the endocrine junctional zone (Jz) of the mouse placenta (Jz-ΔICR1). The Jz-ΔIC ...[more]