Cell cycle-related genes associate with sensitivity to hydrogen peroxide-induced toxicity.

ABSTRACT: Reactive oxygen species (ROS) such as hydrogen peroxide (H₂O₂) are well-described agents in physiology and pathology. Chronic inflammation causes incessant H₂O₂ generation associated with disease occurrences such as diabetes, autoimmunity, and cancer. In cancer, conditioning of the tumor microenvironment, e.g., hypoxia and ROS generation, has been associated with disease outcomes and therapeutic efficacy. Many reports have investigated the roles of the action of H₂O₂ across many cell lines and disease models. The genes predisposing tumor cell lines to H₂O₂-mediated demise are less deciphered, however. To this end, we performed in-house transcriptional profiling of 35 cell lines and simultaneously invest

SUBMITTER: Bekeschus S 

PROVIDER: S-EPMC8783094 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature