Cyanobacteria-based self-oxygenated photodynamic therapy for anaerobic infection treatment and tissue repair.

ABSTRACT: Photodynamic therapy (PDT) is an important technique to deal with drug-resistant bacterial infections in the post-antibiotic era. However, the hypoxic environment in intractable infections such as refractory keratitis and periodontitis, makes PDT more difficult. In this work, spontaneous oxygen-producing cyanobacteria were used as the carrier of photosensitizer (Ce6), and ultrasmall Cu_5.4O nanoparticles (Cu_5.4O USNPs) with catalase activity for infection and inflammation elimination and rapid tissue repair (CeCycn-Cu_5.4O). The loading of Ce6 and Cu_5.4O USNPs onto cyanobacteria surface were confirmed by transmission electron microscopy, nano particle size analyzer, scanning electron microscopy. In vitro sterilization and biofilm removal exp

SUBMITTER: Wang B 

PROVIDER: S-EPMC8783102 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature