Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle.

ABSTRACT:

Objectives

Glucocorticoids (GCs) are one of the most widely prescribed anti-inflammatory drugs. By acting through their cognate receptor, the glucocorticoid receptor (GR), GCs downregulate the expression of pro-inflammatory genes and upregulate the expression of anti-inflammatory genes. Metabolic pathways have recently been identified as key parts of both the inflammatory activation and anti-inflammatory polarization of macrophages, immune cells responsible for acute inflammation and tissue repair. It is currently unknown whether GCs control macrophage metabolism, and if so, to what extent metabolic regulation by GCs confers anti-inflammatory activity.

Methods

Using transcriptomic and metabolomic profiling of macrophages, we identified GC-controlled pathways involved in meta

SUBMITTER: Stifel U 

PROVIDER: S-EPMC8783148 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature