An unexpected role for BAG3 in regulating PARP1 ubiquitination in oxidative stress-related endothelial damage.

ABSTRACT: Oxidative stress-associated endothelial damage is the initiation factor of cardiovascular disease, and protein posttranslational modifications play critical roles in this process. Bcl-2-associated athanogene 3 (BAG3) is a molecular chaperone regulator of the BAG family, which interacts with various proteins and influences cell survival by activating multiple pathways. BAG3 undergoes posttranslational modifications; however, research evaluating BAG3 acetylation and its regulatory mechanism is lacking. In addition, the interacting protein and regulatory mechanism of BAG3 in oxidative stress-associated endothelial damage remain unclear. Here, key molecular interactions and protein modifications of BAG3 were identified in oxidative stress-associated endothelial damage. Endothelial-specific BAG

SUBMITTER: Zhang N 

PROVIDER: S-EPMC8783151 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature