Urinary 11-dehydrothromboxane B₂ concentrations in 20 dogs with primary immune-mediated hemolytic anemia.

ABSTRACT:

Background

Thromboembolic disease is a major cause of mortality in dogs with immune-mediated hemolytic anemia (IMHA). At present, no reliable biomarkers of individual patient thrombotic risk are available. In human medicine, increased urinary thromboxane concentrations have utility as markers of prothrombotic tendency in various situations.

Hypothesis/objectives

First, to determine if urinary 11-dehydrothromboxane B₂ (u11-dTXB) concentrations are increased in dogs with primary IMHA compared to normal dogs; second, to assess whether u11-dTXB concentration is associated with survival, known prognostic indicators, or frequency of thrombosis in dogs with IMHA.

Animals

Twenty client-owned dogs diagnosed with primary IMHA and 17 healthy dogs volunteered by hospit

SUBMITTER: Conway EA 

PROVIDER: S-EPMC8783321 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature