Multicenter, randomized, double-blinded, placebo-controlled study of rabacfosadine in dogs with lymphoma.

ABSTRACT:

Background

Rabacfosadine (RAB, Tanovea-CA1) is a novel chemotherapy agent conditionally approved for the treatment of lymphoma in dogs.

Hypothesis/objectives

To determine the efficacy and safety of RAB in dogs with lymphoma.

Animals

One hundred and fifty-eight client-owned dogs with naïve or relapsed multicentric lymphoma were prospectively enrolled from January to October 2019.

Methods

Dogs were randomized to receive RAB or placebo at a 3 : 1 ratio. Treatment was given every 21 days for up to 5 treatments. Study endpoints included progression-free survival (PFS), overall response rate (ORR) at a given visit, best overall response rate (BORR), and percent progression free 1 month after treatment completion. Safety data were also collected.

Results

The me

SUBMITTER: Weishaar KM 

PROVIDER: S-EPMC8783351 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature