Toxicity of zoledronic acid after intravenous administration: A retrospective study of 95 dogs.

ABSTRACT:

Background

There is a paucity of veterinary literature on the safety or outcome of zoledronic acid (ZA) use in dogs for either bone pain or hypercalcemia.

Hypothesis/objectives

The primary aim was to report the adverse events in dogs receiving intravenous administration of ZA.

Animals

Ninety-five dogs with ZA use.

Methods

A retrospective cohort study was performed; all dogs that received at least 1 dose of ZA and had a serum biochemistry profile performed before and after treatment were reviewed. Diagnosis, indication for treatment, adverse events and survival times were recorded.

Results

Ninety-five dogs met the inclusion criteria. Thirty-one (33%) received multiple intravenous infusions of ZA (range, 2-7), making a total of 166 administrations in all d

SUBMITTER: Brewer DJ 

PROVIDER: S-EPMC8783361 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature