Leptin promoter methylation in female patients with painful multisomatoform disorder and chronic widespread pain.

ABSTRACT:

Background

Different functional somatic syndromes (FSS), fibromyalgia (FMS) and other unexplained painful conditions share many common clinical traits and are characterized by troubling and functionally disabling somatic symptoms. Chronic pain is most frequently reported and at the center of patients' level of disease burden. The construct of multisomatoform disorder (MSD) allows to subsume severely impaired patients suffering from FSS, FMS and other unexplained painful conditions to be examined for common underlying processes. Altered leptin levels and a pathological response of the HPA-axis as a result of chronic stress and childhood trauma have been suggested as one of the driving factors of disease development and severity. Previous studies have demonstrated that methylation of

SUBMITTER: Achenbach J 

PROVIDER: S-EPMC8783406 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature