Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes.

ABSTRACT:

Background

Non-muscle-invasive bladder cancer (NMIBC) patients receive frequent monitoring because ≥ 70% will have recurrent disease. However, screening is invasive, expensive, and associated with significant morbidity making bladder cancer the most expensive cancer to treat per capita. There is an urgent need to expand the understanding of markers related to recurrence and survival outcomes of NMIBC.

Methods and results

We used the Illumina HumanMethylationEPIC array to measure peripheral blood DNA methylation profiles of NMIBC patients (N = 603) enrolled in a population-based cohort study in New Hampshire and applied cell type deconvolution to estimate immune cell-type proportions. Using Cox proportional hazard models, we identified that increasing CD4T and CD8T cell propo

SUBMITTER: Chen JQ 

PROVIDER: S-EPMC8783448 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature