Family and case-control genetic study of MSX1 polymorphisms in peg-shaped teeth Jordanian population.

ABSTRACT:

Background

This study aimed to investigate the genetic association of specific Single Nucleotide Polymorphisms (SNPs) within the muscle segment homeobox gene 1 (MSX1) with susceptibility to the peg-shaped teeth in 36 Jordanian Arab families and case-control samples in the Jordanian Arab population.

Methods

This cohort involved 108 individuals (36 trios families), which were used for family-based genetic study. Additionally, 56 patients and 57 controls were used for case-control study. Genomic DNA samples from both families and case-control were extracted according to distinguished processes. Then, polymerase chain reaction technique (PCR) was conducted using specific primers for the axons of the MSX1. Moreover, DNA sequencing genotyping method analysis of SNPs was used to de

SUBMITTER: Alkhatib R 

PROVIDER: S-EPMC8783454 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature