Use of diagnostic likelihood ratio of outcome to evaluate misclassification bias in the planning of database studies.

ABSTRACT:

Background

The diagnostic likelihood ratio (DLR) and its utility are well-known in the field of medical diagnostic testing. However, its use has been limited in the context of an outcome validation study. We considered that wider recognition of the utility of DLR would enhance the practices surrounding database studies. This is particularly timely and important since the use of healthcare-related databases for pharmacoepidemiology research has greatly expanded in recent years. In this paper, we aimed to advance the use of DLR, focusing on the planning of a new database study.

Methods

Theoretical frameworks were developed for an outcome validation study and a comparative cohort database study; these two were combined to form the overall relationship. Graphical presentations b

SUBMITTER: Ii Y 

PROVIDER: S-EPMC8783524 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature