Skeletal Muscle Regeneration in Advanced Diabetic Peripheral Neuropathy.

ABSTRACT:

Background

Decreased lean muscle mass in the lower extremity in diabetic peripheral neuropathy (DPN) is thought to contribute to altered joint loading, immobility, and disability. However, the mechanism behind this loss is unknown and could derive from a reduction in size of myofibers (atrophy), destruction of myofibers (degeneration), or both. Degenerative changes require participation of muscle stem (satellite) cells to regenerate lost myofibers and restore lean mass. Determining the degenerative state and residual regenerative capacity of DPN muscle will inform the utility of regeneration-targeted therapeutic strategies.

Methods

Biopsies were acquired from 2 muscles in 12 individuals with and without diabetic neuropathy undergoing below-knee amputation surgery. Biopsies w

SUBMITTER: Bohnert KL 

PROVIDER: S-EPMC8783612 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature