C-Jun N-terminal Kinase Mediates Ligand-independent p75^NTR Signaling in Mesencephalic Cells Subjected to Oxidative Stress.

ABSTRACT: The p75 neurotrophin receptor (p75^NTR) is a multifunctional protein that regulates cellular responses to pathological conditions in specific regions of the nervous system. Activation of p75^NTR in certain neuronal populations induces proteolytic processing of the receptor, thereby generating p75^NTR fragments that facilitate downstream signaling. Expression of p75^NTR has been reported in neurons of the ventral midbrain, but p75^NTR signaling mechanisms in such cells are poorly understood. Here, we used Lund Human Mesencephalic cells, a population of neuronal cells derived from the ventral mesencephalon, to evaluate the effects of oxidative stress on p75^NTR signaling. Subjection of the cells to oxidative stress resulted in decre

SUBMITTER: Kraemer BR 

PROVIDER: S-EPMC8783671 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature