Clinical importance of high-mannose, fucosylated, and complex N-glycans in breast cancer metastasis.

ABSTRACT:

Background

Although aberrant glycosylation is recognized as a hallmark of cancer, glycosylation in clinical breast cancer (BC) metastasis has not yet been studied. While preclinical studies show that the glycocalyx coating of cancer cells is involved in adhesion, migration, and metastasis, glycosylation changes from primary tumor (PT) to various metastatic sites remain unknown in patients.

Methods

We investigated N-glycosylation profiles in 17 metastatic BC patients from our rapid autopsy program. Primary breast tumor, lymph node metastases, multiple systemic metastases, and various normal tissue cores from each patient were arranged on unique single-patient tissue microarrays (TMAs). We performed mass spectrometry imaging (MSI) combined with extensive pathology annotation o

SUBMITTER: Scupakova K 

PROVIDER: S-EPMC8783675 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature