Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe H
PROVIDER: S-EPMC8783690 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Watanabe Hirofumi H Martini Alexandre G AG Brown Robin Isadora RI Liang Xiuyin X Medrano Silvia S Goto Shin S Narita Ichiei I Arend Lois J LJ Sequeira-Lopez Maria Luisa S MLS Gomez R Ariel RA
JCI insight 20211222 24
Inhibitors of the renin-angiotensin system (RAS) are widely used to treat hypertension. Using mice harboring fluorescent cell lineage tracers, single-cell RNA-Seq, and long-term inhibition of RAS in both mice and humans, we found that deletion of renin or inhibition of the RAS leads to concentric thickening of the intrarenal arteries and arterioles. This severe disease was caused by the multiclonal expansion and transformation of renin cells from a classical endocrine phenotype to a matrix-secre ...[more]