Harnessing Intranasal Delivery Systems of Sumatriptan for the Treatment of Migraine.

ABSTRACT: Sumatriptan (ST) is a commonly prescribed drug for treating migraine. The efficiency of several routes of ST administration has been investigated. Recently, the intranasal route with different delivery systems has gained interest owing to its fast-acting and effectiveness. The present study is aimed at reviewing the available studies on novel delivery systems for intranasal ST administration. The oral route of ST administration is common but complicated with some problems. Gastroparesis in patients with migraine may reduce the absorption and effectiveness of ST upon oral use. Furthermore, the gastrointestinal (GI) system and hepatic metabolism can alter the pharmacokinetics and clinical effects of ST. The bioavailability of conventional nasal liquids is low due to the deposition of a large

SUBMITTER: Assadpour S 

PROVIDER: S-EPMC8783720 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature