Identification of Key Genes and Pathways in Osteosarcoma by Bioinformatics Analysis.

ABSTRACT:

Purpose

Osteosarcoma (OS) is the most primary bone malignant tumor in adolescents. Although the treatment of OS has made great progress, patients' prognosis remains poor due to tumor invasion and metastasis.

Materials and methods

We downloaded the expression profile GSE12865 from the Gene Expression Omnibus database. We screened differential expressed genes (DEGs) by making use of the R limma software package. Based on Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis, we performed the function and pathway enrichment analyses. Then, we constructed a Protein-Protein Interaction network and screened hub genes through the Search Tool for the Retrieval of Interacting Genes.

Result

By analyzing the gene expression profile GSE12865, we

SUBMITTER: Chen X 

PROVIDER: S-EPMC8783756 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature