Short-term fasting in glioma patients: analysis of diet diaries and metabolic parameters of the ERGO2 trial.

ABSTRACT:

Purpose

The prospective, randomized ERGO2 trial investigated the effect of calorie-restricted ketogenic diet and intermittent fasting (KD-IF) on re-irradiation for recurrent brain tumors. The study did not meet its primary endpoint of improved progression-free survival in comparison to standard diet (SD). We here report the results of the quality of life/neurocognition and a detailed analysis of the diet diaries.

Methods

50 patients were randomized 1:1 to re-irradiation combined with either SD or KD-IF. The KD-IF schedule included 3 days of ketogenic diet (KD: 21-23 kcal/kg/d, carbohydrate intake limited to 50 g/d), followed by 3 days of fasting and again 3 days of KD. Follow-up included examination of cognition, quality of life and serum samples.

Results

The 20 patie

SUBMITTER: Voss M 

PROVIDER: S-EPMC8783850 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature