Transcranial Magnetic Stimulation Indices of Cortical Excitability Enhance the Prediction of Response to Pharmacotherapy in Late-Life Depression.

ABSTRACT:

Background

Older adults with late-life depression (LLD) often experience incomplete or lack of response to first-line pharmacotherapy. The treatment of LLD could be improved using objective biological measures to predict response. Transcranial magnetic stimulation (TMS) can be used to measure cortical excitability, inhibition, and plasticity, which have been implicated in LLD pathophysiology and associated with brain stimulation treatment outcomes in younger adults with depression. TMS measures have not yet been investigated as predictors of treatment outcomes in LLD or pharmacotherapy outcomes in adults of any age with depression.

Methods

We assessed whether pretreatment single-pulse and paired-pulse TMS measures, combined with clinical and demographic measures, predict ven

SUBMITTER: Lissemore JI 

PROVIDER: S-EPMC8783923 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature