Transition from disordered aggregates to ordered lattices: kinetic control of the assembly of a computationally designed peptide.

ABSTRACT: Natural biomolecular self-assembly typically occurs under a narrow range of solution conditions, and the design of sequences that can form prescribed structures under a range of such conditions would be valuable in the bottom-up assembly of predetermined nanostructures. We present a computationally designed peptide that robustly self-assembles into regular arrays under a wide range of solution pH and temperature conditions. Controling the solution conditions provides the opportunity to exploit a simple and reproducible approach for altering the pathway of peptide solution self-assembly. The computationally designed peptide forms a homotetrameric coiled-coil bundle that further self-assembles into 2-D plate structures with well-defined inter-bundle symmetry. Herein, we present how modulatio

SUBMITTER: Tian Y 

PROVIDER: S-EPMC8783983 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature