Intestinal commensal microbiota and cytokines regulate Fut2⁺ Paneth cells for gut defense.

ABSTRACT: Paneth cells are intestinal epithelial cells that release antimicrobial peptides, such as α-defensin as part of host defense. Together with mesenchymal cells, Paneth cells provide niche factors for epithelial stem cell homeostasis. Here, we report two subtypes of murine Paneth cells, differentiated by their production and utilization of fucosyltransferase 2 (Fut2), which regulates α(1,2)fucosylation to create cohabitation niches for commensal bacteria and prevent invasion of the intestine by pathogenic bacteria. The majority of Fut2^- Paneth cells were localized in the duodenum, whereas the majority of Fut2⁺ Paneth cells were in the ileum. Fut2⁺ Paneth cells showed higher granularity and structural complexity than did Fut2^- Paneth cells, suggestin

SUBMITTER: Kamioka M 

PROVIDER: S-EPMC8784097 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature