DNA Repair Pathways and Their Association With Lethal Prostate Cancer in African American and European American Men.

ABSTRACT:

Background

Altered DNA damage response (DDR) has emerged as an important mechanism for the development of aggressive prostate cancer among men of European ancestry but not other ancestry groups. Because common mechanisms for aggressive disease are expected, we explored a large panel of DDR genes and pathways to demonstrate that DDR alterations contribute to development of aggressive prostate cancer in both African American and European American men.

Methods

We performed a case-case study of 764 African American and European American men with lethal or indolent prostate cancer treated at 4 US hospitals. We calculated carrier frequencies of germline pathogenic or likely pathogenic sequence variants within 306 DDR genes, summarized by DDR pathway, and compared lethal cases agai

SUBMITTER: Plym A 

PROVIDER: S-EPMC8784166 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature