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Dumbbell-shaped solid-cystic hypoglossal schwannoma: An unusual case report.

ABSTRACT: Hypoglossal Schwannomas are extremely rare benign slow-growing neoplasms, which originate from the 12th cranial nerve. To date, and to the best of our knowledge, only 40 cases of dumbbell-shaped Hypoglossal Swchannomas have been published in the world literature. We report our experience with a 66 years old male patient, who was diagnosed with a solido-cystic lesion at the right cerebello-pontine angle arising from XIIth cranial nerve. He was treated with surgery via midline suboccipital approach which led to sub-total removal of the tumor and improvement of the symptoms within 3 months. This case highlights the importance of an accurate suspicion diagnosis of hypoglossal schwannoma as well as the treatment options including surgery and radiosurgery.

SUBMITTER: Trifa A

PROVIDER: S-EPMC8784287 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Dumbbell-shaped solid-cystic hypoglossal schwannoma: An unusual case report.

Trifa Amine A Maamri Kais K Cherif Ines I Elkahla Ghassen G Darmoul Mehdi M

Radiology case reports 20220118 3

Hypoglossal Schwannomas are extremely rare benign slow-growing neoplasms, which originate from the 12th cranial nerve. To date, and to the best of our knowledge, only 40 cases of dumbbell-shaped Hypoglossal Swchannomas have been published in the world literature. We report our experience with a 66 years old male patient, who was diagnosed with a solido-cystic lesion at the right cerebello-pontine angle arising from XIIth cranial nerve. He was treated with surgery via midline suboccipital approac ...[more]

PMID: 35106105

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Hybrid endoscopic-microscopic surgery for dumbbell-shaped trigeminal schwannoma: case report and literature review

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Case report: Microsurgical resection of a giant triple dumbbell shaped jugular foramen Schwannoma via retrosigmoid and transcervical approach

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Dumbbell Shaped Schwannoma of the Lateral Chest Wall masquandering as a soft tissue sarcoma.

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A rare case of recurrent primary dumbbell-shaped spinal hydatidosis.

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Unusual location and complication of a cystic lymphangioma: A case report.

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Gene expression profiles between cystic and solid vestibular schwannoma indicate susceptible molecules and pathways in the cystic formation of vestibular schwannoma.

Project description:Previous research has shown that although NF2 gene mutation is the major cause of vestibular schwannoma (VS), it may not directly participate in cystic VS (CVS). To elucidate the underlying potential genetic mechanisms in the cystic formation of VS, we compared differences in gene expression between solid VS (SVS) and CVS via a bioinformatics analysis. The cDNA microarray method and miRNA sequencing were performed on 29 representative VSs (17 CVSs and 12 SVSs). A differential expression analysis was used to identify differentially expressed mRNAs (DEmRNAs) and miRNAs (DEmiRNAs). Then, miRNA-mRNA regulatory networks were constructed. Gene ontology (GO), a KEGG pathway enrichment analysis, and the protein-protein interaction (PPI) were used to analyze the co-differentially expressed DEmRNAs at the functional level. From the differential expression analyses, 1304 DEmRNAs, 55 DEmiRNAs, and hub genes including PTEN, FOXO1, FOXO3, VEGFA, and SIRT1 were identified. Histological evidence is presented to confirm the makeup of the hubs, which corresponded with the cDNA microarray. Our analysis revealed that the maps of apoptosis, cellular response to hypoxia, and the PI3K-Akt, AMPK, FOXO, and chemokine signaling pathways were significantly enriched. In addition, the TUNEL assay, immunoblotting analysis, and transmission electron microscope revealed increased degenerative changes in CVS. These findings could be the foundation for understanding the potential role of differential genes in the cystic formation of VS and be helpful in exploring the potential biomarkers for the differential diagnosis, prognosis, and development of drug targets for CVS.

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Case Report: Rare duodenal schwannoma diagnosis and treatment process report.

Project description:BackgroundDuodenal schwannoma is a rare benign mesenchymal tumor originating from the Schwann cells of peripheral nerves. Its accurate diagnosis remains challenging owing to non-specific clinical and radiological features.Case presentationThis report describes the clinical diagnosis and treatment of a duodenal schwannoma in a 30-year-old female patient. An initial outpatient gastroscopy revealed a submucosal lesion in the duodenum, with differential diagnoses including ectopic pancreas or gastrointestinal stromal tumor. Furthermore, plain and contrast-enhanced abdominal CT scans showed a nodule protruding into the duodenal bulb, suggesting a benign lesion. The patient underwent endoscopic submucosal dissection to remove the tumor. During the procedure, a 1.0 × 1.6 cm submucosal nodule was identified on the anterior wall of the duodenal bulb, with a mildly eroded and slightly depressed surface. The lesion was firm and non-mobile. Histopathological examination of the resected specimen confirmed a spindle cell tumor originating from the duodenal mucosa, leading to a definitive diagnosis of duodenal schwannoma.ConclusionDuodenal schwannoma is a rare submucosal tumor traditionally treated with surgical resection. This case highlights the safety and efficacy of endoscopic submucosal dissection in the treatment of duodenal schwannomas, allowing complete tumor resection while preserving gastrointestinal function. In addition, early detection and complete resection are key for preventing recurrence and potential complications.

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Schwannoma of the sympathetic trunk: A case report.

Project description:Introduction and importanceSchwannomas are benign tumors commonly found in the cranial vault at the cerebellopontine angle. Schwannomas could arise from any nerve that has Schwann sheath. Their most common extra-cranial localization is the parapharyngeal space. Schwannomas do not usually metastasize, and recurrence is uncommon.Case presentationWe present a case of a sympathetic trunk schwannoma in a patient that presented with dysphagia and a painful neck mass. Oro-pharyngeal examination revealed the presence of a mass filling-up the left tonsillar fossa, and pushing the uvula to the right side. The larynx was also deviated to the right due to the mass effect. The mass was resected en-bloc with the involved part of the sympathetic trunk. The patient developed Horner's syndrome postoperatively.Clinical discussionThe occurrence of Sympathetic trunk Schwannomas is very rare. The majority of patients presented with a cervical mass and non-specific symptoms. The most effective treatment is surgical resection. Our experience suggests sympathetic trunk Schwannomas as a differential diagnosis of slow-growing neck masses and asserts that the surgical resection is the main treatment.ConclusionThe occurrence of Schwannomas in the sympathetic trunk is rare. High clinical suspicion is required to achieve the preoperative diagnosis. The optimal management is the total surgical resection. Recurrence is uncommon when the mass is totally resected.

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Dumbbell-Shaped Rhabdomyosarcoma: Two-Stage Surgical Resection.

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