Corynebacterium Species Inhibit Streptococcus pneumoniae Colonization and Infection of the Mouse Airway.

ABSTRACT: The stability and composition of the airway microbiome is an important determinant of respiratory health. Some airway bacteria are considered to be beneficial due to their potential to impede the acquisition and persistence of opportunistic bacterial pathogens such as Streptococcus pneumoniae. Among such organisms, the presence of Corynebacterium species correlates with reduced S. pneumoniae in both adults and children, in whom Corynebacterium abundance is predictive of S. pneumoniae infection risk. Previously, Corynebacterium accolens was shown to express a lipase which cleaves host lipids, resulting in the production of fatty acids that inhibit growth of S. pneumoniae in vitro. However, it was unclear whether this mechanism contributes to

SUBMITTER: Horn KJ 

PROVIDER: S-EPMC8784410 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature