Insights on the mutational landscape of the SARS-CoV-2 Omicron variant receptor-binding domain.

ABSTRACT: The Omicron variant features enhanced transmissibility and antibody escape. Here, we describe the Omicron receptor-binding domain (RBD) mutational landscape using amino acid interaction (AAI) networks, which are well suited for interrogating constellations of mutations that function in an epistatic manner. Using AAI, we map Omicron mutations directly and indirectly driving increased escape breadth and depth in class 1-4 antibody epitopes. Further, we present epitope networks for authorized therapeutic antibodies and assess perturbations to each antibody's epitope. Since our initial modeling following the identification of Omicron, these predictions have been realized by experimental findings of Omicron neutralization escape from therapeutic antibodies ADG20, AZD8895, and AZD1061. Important

SUBMITTER: Miller NL 

PROVIDER: S-EPMC8784435 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature