Long-term morbidity and mortality in patients diagnosed with an insulinoma.

ABSTRACT:

Objective

Insulinomas are rare functional pancreatic neuroendocrine tumours. As previous data on the long-term prognosis of insulinoma patients are scarce, we studied the morbidity and mortality in the Finnish insulinoma cohort.

Design

Retrospective cohort study.

Methods

Incidence of endocrine, cardiovascular, gastrointestinal and psychiatric disorders, and cancers was compared in all the patients diagnosed with an insulinoma in Finland during 1980-2010 (n = 79, including two patients with multiple endocrine neoplasia type 1 syndrome), vs 316 matched controls, using the Mantel-Haenszel method. Overall survival was analysed with Kaplan-Meier and Cox regression analyses.

Results

The median length of follow-up was 10.7 years for the patients and 12.2 years for the

SUBMITTER: Peltola E 

PROVIDER: S-EPMC8784472 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature