A pilot study of multilevel analysis of BDNF in paternal and maternal perinatal depression.

ABSTRACT: Depression in the perinatal period is common in mothers worldwide. Emerging research indicates that fathers are also at risk of developing perinatal depression. However, knowledge regarding biological risk factors and pathophysiological mechanisms of perinatal depression is still scarce, particularly in fathers. It has been suggested that the neurotrophin BDNF may play a role in maternal perinatal depression; however, there is currently no data regarding paternal perinatal depression. For this pilot study, 81 expecting parents were recruited and assessed at several time points. We screened for depression using EPDS and MADRS, investigated several psychosocial variables, and took blood samples for BDNF val66met genotyping, epigenetic, and protein analysis. Between pregnancy and 12 months po

SUBMITTER: Kittel-Schneider S 

PROVIDER: S-EPMC8784499 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature