The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation.

ABSTRACT: Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of deaths across the world. Since the discovery of scarless functional healing in fetuses prior to a certain stage of development, scientists have attempted to replicate scarless wound healing in adults with little success. While the extracellular matrix (ECM), fibroblasts, and inflammatory mediators have been historically investigated as separate branches of biology, it has become increasingly necessary to consider them as parts of a complex and tightly regulated system that becomes dysregulated in fibrosis. With this new paradigm, revisiting fetal scarless wound healing provides a unique opportunity to better understand how this highly regulated system operates mechanistically. In the following revi

SUBMITTER: Moretti L 

PROVIDER: S-EPMC8784641 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature