Prospective Clinical Feasibility Study for MRI-Only Brain Radiotherapy.

ABSTRACT:

Objectives

MRI-only radiotherapy (RT) provides a workflow to decrease the geometric uncertainty introduced by the image registration process between MRI and CT data and to streamline the RT planning. Despite the recent availability of validated synthetic CT (sCT) methods for the head region, there are no clinical implementations reported for brain tumors. Based on a preceding validation study of sCT, this study aims to investigate MRI-only brain RT through a prospective clinical feasibility study with endpoints for dosimetry and patient setup.

Material and methods

Twenty-one glioma patients were included. MRI Dixon images were used to generate sCT images using a CE-marked deep learning-based software. RT treatment plans were generated based on MRI delineated anatomical struc

SUBMITTER: Lerner M 

PROVIDER: S-EPMC8784680 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature