Serum and salivary immunoglobulin G4 levels in children with autism spectrum disorder from south India: a case-control study.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with wide spectrum of symptoms and few effective therapies. Evidence is suggestive of an association between immune system dysfunction and autism spectrum disorders (ASD) among children with ASD. Immunoglobulins (Ig) are found to be increased in the circulation of individuals with autism. The prospective study was aimed to estimate and correlate the levels of IgG4 in blood and saliva of children with autism.

Methodology

Blood and unstimulated saliva were collected from 172 children (55 ASD, 57 healthy control, and 60 suspected parasitic infection) aged 0-18 years. Routine blood investigations were done. Serum and salivary IgG4 levels were analyzed using a commercially available enzyme-linked i

SUBMITTER: Bhat SS 

PROVIDER: S-EPMC8784761 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature