Ontology highlight
ABSTRACT:
SUBMITTER: Takele Y
PROVIDER: S-EPMC8784791 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Takele Yegnasew Y Mulaw Tadele T Adem Emebet E Shaw Caroline Jayne CJ Franssen Susanne Ursula SU Womersley Rebecca R Kaforou Myrsini M Taylor Graham Philip GP Levin Michael M Müller Ingrid I Cotton James Anthony JA Kropf Pascale P
Cell reports. Medicine 20211230 1
Visceral leishmaniasis (VL) has emerged as a clinically important opportunistic infection in HIV patients, as VL/HIV co-infected patients suffer from frequent VL relapse. Here, we follow cohorts of VL patients with or without HIV in Ethiopia. By the end of the study, 78.1% of VL/HIV-but none of the VL patients-experience VL relapse. Despite a clinically defined cure, VL/HIV patients maintain higher parasite loads, lower BMI, hepatosplenomegaly, and pancytopenia. We identify three immunological m ...[more]