Effects of Cage Position and Light Transmission on Home Cage Activity and Circadian Entrainment in Mice.

ABSTRACT: Light is known to exert powerful effects on behavior and physiology, including upon the amount and distribution of activity across the day/night cycle. Here we use home cage activity monitoring to measure the effect of differences in home cage light spectrum and intensity on key circadian activity parameters in mice. Due to the relative positioning of any individually ventilated cage (IVC) with regard to the animal facility lighting, notable differences in light intensity occur across the IVC rack. Although all mice were found to be entrained, significant differences in the timing of activity onset and differences in activity levels were found between mice housed in standard versus red filtering cages. Furthermore, by calculating the effective irradiance based upon the known mouse photopig

SUBMITTER: Steel LCE 

PROVIDER: S-EPMC8784806 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature