Smoothened/AMP-Activated Protein Kinase Signaling in Oligodendroglial Cell Maturation.

ABSTRACT: The regeneration of myelin is known to restore axonal conduction velocity after a demyelinating event. Remyelination failure in the central nervous system contributes to the severity and progression of demyelinating diseases such as multiple sclerosis. Remyelination is controlled by many signaling pathways, such as the Sonic hedgehog (Shh) pathway, as shown by the canonical activation of its key effector Smoothened (Smo), which increases the proliferation of oligodendrocyte precursor cells via the upregulation of the transcription factor Gli1. On the other hand, the inhibition of Gli1 was also found to promote the recruitment of a subset of adult neural stem cells and their subsequent differentiation into oligodendrocytes. Since Smo is also able to transduce Shh signals via v

SUBMITTER: Del Giovane A 

PROVIDER: S-EPMC8784884 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature