Signature of arylacetamide deacetylase expression is associated with prognosis and immune infiltration in ovarian cancer.

ABSTRACT:

Objective

The role of the protein-coding gene arylacetamide deacetylase (AADAC) in the prognostication of ovarian cancer remains uncertain. We aimed to identify and validate its prognostic value using integrated bioinformatics analyses.

Methods

Gene expression profiles of RNA-sequencing and microarray data were retrieved from The Cancer Genome Atlas and Gene Expression Omnibus. Univariate and multivariate Cox regression models were used to evaluate the prognostic value of gene expression. The predictive accuracy of the gene signature model was evaluated using a time-dependent receiver operating characteristic (ROC) curve. In addition, the correlation between immune infiltration and AADAC was identified. A nomogram of the gene signature with clinical parameters was constructe

SUBMITTER: Feng J 

PROVIDER: S-EPMC8784941 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature