Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives.

ABSTRACT:

Rationale

The chronic mild stress (CMS) paradigm was first described almost 40 years ago and has become a widely used model in the search for antidepressant drugs for major depression disorder (MDD). It has resulted in the publication of almost 1700 studies in rats alone. Under the original CMS procedure, the expression of an anhedonic response, a key symptom of depression, was seen as an essential feature of both the model and a depressive state. The prolonged exposure of rodents to unpredictable/uncontrollable mild stressors leads to a reduction in the intake of palatable liquids, behavioral despair, locomotor inhibition, anxiety-like changes, and vegetative (somatic) abnormalities. Many of the CMS studies do not report these patterns of behaviors, and they often fail to include

SUBMITTER: Strekalova T 

PROVIDER: S-EPMC8785013 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature