Ontology-based identification and prioritization of candidate drugs for epilepsy from literature.

ABSTRACT:

Background

Drug repurposing can improve the return of investment as it finds new uses for existing drugs. Literature-based analyses exploit factual knowledge on drugs and diseases, e.g. from databases, and combine it with information from scholarly publications. Here we report the use of the Open Discovery Process on scientific literature to identify non-explicit ties between a disease, namely epilepsy, and known drugs, making full use of available epilepsy-specific ontologies.

Results

We identified characteristics of epilepsy-specific ontologies to create subsets of documents from the literature; from these subsets we generated ranked lists of co-occurring neurological drug names with varying specificity. From these ranked lists, we observed a high intersection regarding re

SUBMITTER: Muller B 

PROVIDER: S-EPMC8785029 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature