Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish.

ABSTRACT: Developmental consequences of prenatal drug exposure have been reported in many human cohorts and animal studies. The long-lasting impact on the offspring-including motor and cognitive impairments, cranial and cardiac anomalies and increased prevalence of ADHD-is a socioeconomic burden worldwide. Identifying the molecular changes leading to developmental consequences could help ameliorate the deficits and limit the impact. In this study, we have used zebrafish, a well-established behavioral and genetic model with conserved drug response and reward pathways, to identify changes in behavior and cellular pathways in response to developmental exposure to amphetamine, nicotine or oxycodone. In the presence of the drug, exposed animals showed altered behavior, consistent with effects seen in mam

SUBMITTER: Mech AM 

PROVIDER: S-EPMC8785235 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature