Prognostic value of the immune target CEACAM6 in cancer: a meta-analysis.

ABSTRACT:

Background

Identification of membrane proteins differentially expressed on tumor cells is a key step in drug development. The carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is a cell adhesion protein belonging to the immunoglobulin superfamily. Here, we explore the prognostic role CEACAM6 expression on patient outcome in cancer.

Methods

A systematic search for studies evaluating the association between tumor expression of CEACAM6 and overall survival (OS) and disease-free survival (DFS) was performed. Hazard ratios (HR) were pooled in a meta-analysis using generic inverse variance and random effect modeling. Subgroup analyses were conducted based on tumor type and method of HR extraction.

Results

Sixteen studies met the inclusion criteria. CEACAM6

SUBMITTER: Burgos M 

PROVIDER: S-EPMC8785271 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature