Temporal transitions in the post-mitotic nervous system of Caenorhabditis elegans.

ABSTRACT: In most animals, the majority of the nervous system is generated and assembled into neuronal circuits during embryonic development¹. However, during juvenile stages, nervous systems still undergo extensive anatomical and functional changes to eventually form a fully mature nervous system by the adult stage^2,3. The molecular changes in post-mitotic neurons across post-embryonic development and the genetic programs that control these temporal transitions are not well understood^4,5. Here, using the model system Caenorhabditis elegans, we comprehensively characterized the distinct functional states (locomotor behaviour) and the corresponding distinct molecular states (transcriptome) of the post-mitotic nervous system across temporal transitions during post-embr

SUBMITTER: Sun H 

PROVIDER: S-EPMC8785361 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature