Temperature Cycling Enables Efficient ¹³C SABRE-SHEATH Hyperpolarization and Imaging of [1-¹³C]-Pyruvate.

ABSTRACT: Molecular metabolic imaging in humans is dominated by positron emission tomography (PET). An emerging nonionizing alternative is hyperpolarized MRI of ¹³C-pyruvate, which is innocuous and has a central role in metabolism. However, similar to PET, hyperpolarized MRI with dissolution dynamic nuclear polarization (d-DNP) is complex costly, and requires significant infrastructure. In contrast, Signal Amplification By Reversible Exchange (SABRE) is a fast, cheap, and scalable hyperpolarization technique. SABRE in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) can transfer polarization from parahydrogen to ¹³C in pyruvate; however, polarization levels remained low relative to d-DNP (1.7% with SABRE-SHEATH versus ≈60% with DNP). Here we introduce a temperat

SUBMITTER: TomHon P 

PROVIDER: S-EPMC8785411 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature