Case-control study on TP73 rs1801173 C > T gene polymorphism and susceptibility to gastric cancer in a Chinese Han population.

ABSTRACT:

Background

This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer.

Methods

We conducted a case-controlled study including 577 primary gastric cancer and 678 normal control cases. The target gene fragment was amplified using PCR using blood samples collected from patients. Allele analysis and genotyping were performed using snapshot method.

Results

The findings showed that the control group had consistent genotype frequency distribution and presented Hardy-Weinberg equilibrium. The results showed no significant differences in sex, drinking history and age distributions between subjects with the polymorphism and subjects in the control group. Smoking status was correlated with incidence of gastric cancer (P = 0.006). The rs1801173

SUBMITTER: Pan H 

PROVIDER: S-EPMC8785439 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature